Löwenberg EC, Meijers JC, Monia BP, Levi M. J Thromb Haemost. 2010 Nov;8(11):2349-57. doi: 10.1111/j.1538-7836.2010.04031.x. Coagulation factor (F)XI was first described as a member of the contact pathway of coagulation. However, the ‘classic’ theory of the extrinsic and intrinsic pathway has been revised and FXI was found to be activated by thrombin and to play a role in sustained [...]
View Post factor XI, thromboembolic, thrombosisDi Cera E. Prog Mol Biol Transl Sci. 2011;99:145-84. Thrombosis is the most prevalent cause of fatal diseases in developed countries. An antithrombotic agent that can be administered to patients with severe acute thrombotic diseases without the risk of causing hemorrhage, as experienced with antithrombotic/thrombolytic therapy in the treatment of acute ischemic stroke or systemic anticoagulants [...]
View Post antithrombotic, ischemic stroke, protease-activated receptors, Protein C, protein C activation, thrombolytic therapy, thrombosisFurlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W. J Clin Invest. 2011 Jul;121(7):2932-44. doi: 10.1172/JCI46129. Epub 2011 Jun 13. Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant activity. However, the molecular pathways that generate prothrombotic TF in vivo are poorly defined. [...]
View Post prothrombotic, thrombosisSalomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U. Thromb Haemost. 2011 Feb;105(2):269-73. Epub 2010 Nov 5. Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We [...]
View Post factor XI, fibrinolysis, thrombosisSiegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Circulation. 2010 Nov 2;122(18):1854-61. Epub 2010 Oct 18. BACKGROUND: Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis [...]
View Post coagulation, kallikrein, thrombosisQiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber and David Gailani Blood November 11, 2010 vol. 116 no. 19 3981-3989 Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to [...]
View Post 14E11, arterial occlusion, factor XI, factor XII, FXI, fXI activation, fXII, hemostasis, thrombosis, thrombus formation in vivoEmsley J, McEwan PA, Gailani D. Blood. 2010 Apr 1;115(13):2569-77. Epub 2010 Jan 28. Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX. Although bleeding associated with FXI deficiency is relatively mild, there has been resurgence of interest in FXI because of studies indicating it makes contributions to thrombosis [...]
View Post factor XI, thrombosisMüller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, Schmidbauer S, Gahl WA, Morrissey JH, Renné T. Cell. 2009 Dec 11;139(6):1143-56. Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60-100 phosphate residues that directly bound to and activated the plasma protease factor XII. PolyP-driven factor XII activation triggered [...]
View Post bradykinin, kallikrein, procoagulant, pulmonary embolism, thrombosisRenné T, Oschatz C, Seifert S, Müller F, Antovic J, Karlman M, Benz PM. J Thromb Haemost. 2009 Jul;7 Suppl 1:79-83. The blood coagulation system forms fibrin to limit blood loss from sites of injury, but also contributes to occlusive diseases such as deep vein thrombosis, myocardial infarction, and stroke. In the current model of a coagulation balance, normal hemostasis and thrombosis [...]
View Post Anticoagulant, factor XI, thrombosisGailani D, Renné T. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2507-13. Epub 2007 Oct 4. Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that [...]
View Post factor XI, factor XII, fibrin formation, protease-activated receptors, thrombosis