Pham M, Stoll G, Nieswandt B, Bendszus M, Kleinschnitz C. J Mol Med (Berl). 2012 Feb;90(2):119-26. Epub 2011 Sep 10. Ischemic stroke is a devastating disease which, in most cases, is caused by thrombotic occlusion of brain arteries. The molecular mechanisms involved in microvascular thrombus formation during focal cerebral ischemia are not well understood. As a consequence, the current antithrombotic [...]
View Post factor XII, fibrin, ischemic stroke, thromboembolismLuo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST. Infect Immun. 2012 Jan;80(1):91-9. Epub 2011 Oct 17. In mice infected sublethally with Listeria monocytogenes, fibrin is deposited at low levels within hepatic tissue, where it functions protectively by limiting bacterial growth and suppressing hemorrhagic pathology. Here we demonstrate that mice infected with lethal doses of L. [...]
View Post bacterial growth, coagulopathy, factor XI, fibrin, inflammation, listeria, listeriosisMüller F, Gailani D, Renné T. Curr Opin Hematol. 2011 Sep;18(5):349-55. Arterial and venous thrombosis are major causes of morbidity and mortality, and the incidence of thromboembolic diseases increases as a population ages. Thrombi are formed by activated platelets and fibrin. The latter is a product of the plasma coagulation system. Currently available anticoagulants such as heparins, vitamin [...]
View Post Anticoagulation, arterial thrombosis, factor Xa, fibrin, fibrin formation, hemostasis, Thrombin, thromboembolic, VENOUS THROMBOSIS