Pham M, Stoll G, Nieswandt B, Bendszus M, Kleinschnitz C. J Mol Med (Berl). 2012 Feb;90(2):119-26. Epub 2011 Sep 10. Ischemic stroke is a devastating disease which, in most cases, is caused by thrombotic occlusion of brain arteries. The molecular mechanisms involved in microvascular thrombus formation during focal cerebral ischemia are not well understood. As a consequence, the current antithrombotic [...]
View Post factor XII, fibrin, ischemic stroke, thromboembolismNieswandt B, Kleinschnitz C, Stoll G. J Physiol. 2011 Sep 1;589(Pt 17):4115-23. Epub 2011 Jul 18. Ischaemic stroke is a leading cause of death and disability worldwide. The complex cellular interactions leading from thromboembolic vessel occlusion to infarct development within the brain parenchyma in acute stroke are poorly understood, which translates into only one approved effective treatment, thrombolysis. [...]
View Post factor XII, ischemic stroke, von Willebrand factorLiver Int. 2011 Feb;31(2):176-83. doi: 10.1111/j.1478-3231.2010.02375.x. Epub 2010 Dec 7. Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietiläinen KH, Lundbom N, Rissanen A, Lassila R, Yki-Järvinen H. BACKGROUND AND AIMS: Obesity and the metabolic syndrome are established risk factors of venous thromboembolism. As most coagulation factors are produced exclusively by the liver and non-alcoholic fatty liver disease (NAFLD) is tightly related to [...]
View Post Factor IX, Factor VIII, Factor X, factor XI, factor XII, liver, liver diseaseCheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D. Blood. 2010 Nov 11;116(19):3981-9. Epub 2010 Jul 15. Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance [...]
View Post factor XI, factor XII, thrombus formationSiegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Circulation. 2010 Nov 2;122(18):1854-61. Epub 2010 Oct 18. Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred [...]
View Post factor XI, factor XII, ischemic stroke, protein activationQiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber and David Gailani Blood November 11, 2010 vol. 116 no. 19 3981-3989 Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to [...]
View Post 14E11, arterial occlusion, factor XI, factor XII, FXI, fXI activation, fXII, hemostasis, thrombosis, thrombus formation in vivoTucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR. Blood. 2009 Jan 22;113(4):936-44. Epub 2008 Oct 22. The protease thrombin is required for normal hemostasis and pathologic thrombogenesis. Since the mechanism of coagulation factor XI (FXI)-dependent thrombus growth remains unclear, we investigated the contribution of FXI to thrombus formation in a primate thrombosis model. Pretreatment [...]
View Post antithrombotic, aXIMab, factor XI, factor XII, fibrin formation, ThrombinGailani D, Renné T. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2507-13. Epub 2007 Oct 4. Formation of a fibrin clot is mediated by a group of tightly regulated plasma proteases and cofactors. While this system is essential for minimizing blood loss from an injured blood vessel (hemostasis), it also contributes to pathologic fibrin formation and platelet activation that [...]
View Post factor XI, factor XII, fibrin formation, protease-activated receptors, thrombosisDoggen CJ, Rosendaal FR, Meijers JC. Blood. 2006 Dec 15;108(13):4045-51. Epub 2006 Aug 24. The role of the intrinsic coagulation system on the risk of myocardial infarction is unclear. In the Study of Myocardial Infarctions Leiden (SMILE) that included 560 men younger than age 70 with a first myocardial infarction and 646 control subjects, we investigated the risk [...]
View Post coagulation, Factor IXc, factor VIIIc, factor XI, factor XII, myocardial infarctionIwaki T, Castellino FJ. Thromb Haemost. 2006 Jun;95(6):1003-10. A genetically-transmissible factor (F) XII-inactivated allele has been produced in mice by targeted replacement of exons 3-8 of the FXII gene with the neomycin resistance gene. Interbreeding of these mice provided offspring homozygous for two inactivated FXII alleles (FXII(-/-)). Male and female FXII-deficient mice bred normally in all genotypic [...]
View Post bradykinin, factor XII