Leung PY, Hurst S, Berny-Lang MA, Verbout NG, Gailani D, Tucker EI, Wang RK, McCarty OJT, Gruber A. Translational Stroke Research 2012. Epub 2012 May 3. Blood coagulation factor XI (FXI) is an established risk factor for acute ischemic stroke (AIS) and thrombosis, but is also needed for normal hemostasis. Contact factor XII (FXII), an [...]
View Post factor XI, hemostasis, Ischemia, Neuroprotection, thrombolysisLöwenberg EC, Meijers JC, Monia BP, Levi M. J Thromb Haemost. 2010 Nov;8(11):2349-57. doi: 10.1111/j.1538-7836.2010.04031.x. Coagulation factor (F)XI was first described as a member of the contact pathway of coagulation. However, the ‘classic’ theory of the extrinsic and intrinsic pathway has been revised and FXI was found to be activated by thrombin and to play a role in sustained [...]
View Post factor XI, thromboembolic, thrombosisLuo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST. Infect Immun. 2012 Jan;80(1):91-9. Epub 2011 Oct 17. In mice infected sublethally with Listeria monocytogenes, fibrin is deposited at low levels within hepatic tissue, where it functions protectively by limiting bacterial growth and suppressing hemorrhagic pathology. Here we demonstrate that mice infected with lethal doses of L. [...]
View Post bacterial growth, coagulopathy, factor XI, fibrin, inflammation, listeria, listeriosisSalomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U. Thromb Haemost. 2011 Feb;105(2):269-73. Epub 2010 Nov 5. Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We [...]
View Post factor XI, fibrinolysis, thrombosisLiver Int. 2011 Feb;31(2):176-83. doi: 10.1111/j.1478-3231.2010.02375.x. Epub 2010 Dec 7. Kotronen A, Joutsi-Korhonen L, Sevastianova K, Bergholm R, Hakkarainen A, Pietiläinen KH, Lundbom N, Rissanen A, Lassila R, Yki-Järvinen H. BACKGROUND AND AIMS: Obesity and the metabolic syndrome are established risk factors of venous thromboembolism. As most coagulation factors are produced exclusively by the liver and non-alcoholic fatty liver disease (NAFLD) is tightly related to [...]
View Post Factor IX, Factor VIII, Factor X, factor XI, factor XII, liver, liver diseaseZhang H, Löwenberg EC, Crosby JR, MacLeod AR, Zhao C, Gao D, Black C, Revenko AS, Meijers JC, Stroes ES, Levi M, Monia BP. Blood. 2010 Nov 25;116(22):4684-92. Epub 2010 Aug 31. Existing anticoagulants effectively inhibit the activity of coagulation factors of the extrinsic and common pathway but have substantial limitations and can cause severe bleeding complications. Here we describe a novel therapeutic approach to thrombosis treatment. [...]
View Post Anticoagulant, factor XI, thromboembolismCheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D. Blood. 2010 Nov 11;116(19):3981-9. Epub 2010 Jul 15. Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance [...]
View Post factor XI, factor XII, thrombus formationSiegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Circulation. 2010 Nov 2;122(18):1854-61. Epub 2010 Oct 18. Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred [...]
View Post factor XI, factor XII, ischemic stroke, protein activationQiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber and David Gailani Blood November 11, 2010 vol. 116 no. 19 3981-3989 Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to [...]
View Post 14E11, arterial occlusion, factor XI, factor XII, FXI, fXI activation, fXII, hemostasis, thrombosis, thrombus formation in vivoTakahashi M, Yamashita A, Moriguchi-Goto S, Sugita C, Matsumoto T, Matsuda S, Sato Y, Kitazawa T, Hattori K, Shima M, Asada Y. Thromb Res. 2010 May;125(5):464-70. Epub 2010 Jan 20. Abstract INTRODUCTION: In addition to acquired and inherited risk factors, the growth of venous thrombus under static conditions and endothelial injury play important roles in the development of deep venous thrombosis (DVT), for which risk factors [...]
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