Siegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Circulation. 2010 Nov 2;122(18):1854-61. Epub 2010 Oct 18. BACKGROUND: Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis [...]
View Post coagulation, kallikrein, thrombosisSiegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A. Circulation. 2010 Nov 2;122(18):1854-61. Epub 2010 Oct 18. Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred [...]
View Post factor XI, factor XII, ischemic stroke, protein activationWong PC, Jiang X. Thromb Haemost. 2010 Aug;104(2):302-10. Epub 2010 Jun 29. Apixaban is an oral, direct and highly selective factor Xa (FXa) inhibitor in late-stage clinical development. This study evaluated the in vitro effect of apixaban on human platelet aggregation induced by thrombin derived via the extrinsic pathway. Direct inhibitors of FXa (rivaroxaban), FVIIa (BMS-593214), thrombin [...]
View Post factor Xa, FXIaRuf W, Ruggeri ZM. Nat Med. 2010 Aug;16(8):887-96. Blood coagulation protects from microbial infections. A recent study now shows that neutrophils fine tune the procoagulant response to invading pathogens. Neutrophils degrade an inhibitor of coagulation, locally ‘trapping’ bacteria in small blood vessels. But they also increase blood clots in large vessels in the absence of infection, [...]
View Post coagulation, microbial infections, neutrophils, procoagulantQiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber and David Gailani Blood November 11, 2010 vol. 116 no. 19 3981-3989 Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to [...]
View Post 14E11, arterial occlusion, factor XI, factor XII, FXI, fXI activation, fXII, hemostasis, thrombosis, thrombus formation in vivoMarino F, Pelc LA, Vogt A, Gandhi PS, Di Cera E. J Biol Chem. 2010 Jun 18;285(25):19145-52. Epub 2010 Apr 19. Thrombin elicits functional responses critical to blood homeostasis by interacting with diverse physiological substrates. Ala-scanning mutagenesis of 97 residues covering 53% of the solvent accessible surface area of the enzyme identifies Trp(215) as the single most important determinant of [...]
View Post autolysis loop, fibrinogen, Protein C, protein C activation, W215AWhite-Adams TC, Berny MA, Patel IA, Tucker EI, Gailani D, Gruber A, McCarty OJT. J Thromb Haemost 2010; 8: 1295–301. BACKGROUND: Laminin is the most abundant non-collagenous protein in the basement membrane. Recent studies have shown that laminin supports platelet adhesion, activation and aggregation under flow conditions, highlighting a possible role for laminin in hemostasis. [...]
View Post basement membrane, fibrin formation, FXI, fXII, hemostasis, Laminin, platelet activation, platelet adhesion, platelet aggregation, recalcified plasma, thrombus formationSchumacher WA, Luettgen JM, Quan ML, Seiffert DA. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):388-92. Epub 2010 Feb 5. The dose-limiting issue with available anticoagulant therapies is bleeding. Is there an approach that could provide antithrombotic protection with reduced bleeding? One hypothesis is that targeting proteases upstream from the common pathway provides a reduction in thrombin sufficient to impede occlusive [...]
View Post antithrombotic, coagulation, FXIa, hemostasis, thrombin generation, thromboembolic, thromboembolismTakahashi M, Yamashita A, Moriguchi-Goto S, Sugita C, Matsumoto T, Matsuda S, Sato Y, Kitazawa T, Hattori K, Shima M, Asada Y. Thromb Res. 2010 May;125(5):464-70. Epub 2010 Jan 20. Abstract INTRODUCTION: In addition to acquired and inherited risk factors, the growth of venous thrombus under static conditions and endothelial injury play important roles in the development of deep venous thrombosis (DVT), for which risk factors [...]
View Post coagulation, factor XIEmsley J, McEwan PA, Gailani D. Blood. 2010 Apr 1;115(13):2569-77. Epub 2010 Jan 28. Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX. Although bleeding associated with FXI deficiency is relatively mild, there has been resurgence of interest in FXI because of studies indicating it makes contributions to thrombosis [...]
View Post factor XI, thrombosis